الفهرس 
Introduction & Aim of workOnly 14 pages are availabe for public view
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Abstract
Atopic dermatitis (AD) is a chronic, pruritic skin condition that is very common in children but may occur at any age. It is usually associated with other atopic disorders.IL-33 is a member of the IL-1 family of cytokines. IL-33 functions as an ‘alarmin’ that belongs to the larger family of damage-associated molecular pattern (DAMP) molecules. It has a role in numerous dermatologic diseases e.g. allergic contact dermatitis, chronic spontaneous urticaria, bullous pemphigoid, vitiligo, psoriasis connective tissue diseases & AD which is the topic of our research.The present study aim was to evaluate serum IL-33 level in patients with AD & to evaluate its correlation with disease severity, activity and serum IgE level. The study comprised 40 patients and 40 age and sex matched controls.In the current study, IL-33 levels were statistically highly significant in AD patients in comparison to controls. Statistically there was no significant relationship of serum IL-33 with age. However the mean value of serum IL-33 was higher in patients ≤ 5 years than in patients> 5 years.Regarding severity of AD, serum IL-33 showed significant statistical difference between mild, moderate and severe cases according to SCORAD. The level of IL-33 was the highest among severe then moderate then mild cases.There was statistically significant difference in serum level of IgE between cases & control groups, and there was significant positive statistical correlation between serum IL-33 and serum IgE levels.Serum IgE level also showed a statistically significant difference as regard severity to be the highest in severe followed by moderate then mild cases according to SCORAD.