الفهرس 
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Abstract
Aim of the Work:
The aim of this study was to investigate the protective effect of curcumin and CoQ10 on CCl4-induced liver fibrosis in rats by evaluating gene expression of TIMP-1 and TIMP-2, assessment of hepatic level of TNF–, measuring different parameters of antioxidant activity as well as performing histopathological studies.
According to these results, it is clear that CoQ10 effectively protected against the chronic hepatotoxicity induced by CCl4 in rats. The hepatoprotective effect afforded by CoQ10 can be attributed to its antioxidant and anti-inflammatory activities. Therefore, CoQ10 might be considered a potential therapeutic tool to prevent liver tissue injury.
Also the results of the present study indicated that curcumin treatment prevented the development of hepatic fibrosis in rats that were administered the hepatotoxin CCl4. As curcumin is safe for consumption by humans, it may have a beneficial role in CLDs by ameliorating lipid peroxidation and down-regulating the expression and content of pro-inflammatory cytokines. Also co-administration of CoQ10 along with curcumin prevented liver fibrosis by maintaining normal liver antioxidant activity and down-regulating the expression of pro-inflammatory cytokines. However combined treatment with CoQ10 and curcumin did not provide significant effect over CoQ10 or curcumin alone.
Conclusion and recommendation:
According to these results, it may be concluded that administration of curcumin and CoQ10 may prevent initiation and propagation of CLDs. However, combined treatment with CoQ10 and curcumin did not provide additional prophylactic effect. However this combined therapy needs further additional basic and clinical studies to prove the results.