الفهرس 
Dedication
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Abstract
The present study was carried out on 50 cattle suffering from lesions suggestive of bovine Papilloma. The animal was of both sex and of different ages range from 9 months to 4 years. The animal was collected from EL-Dakhla center, New Valley Governorate.
The animal was exposed to the following studies:
I- History of the case: sex, age.
II- clinical examination of the swelling according to (Pascoe and Knottenbelt, 1999) include:
1- Size of the swelling
2- Multiplicity of the swelling
3- Anatomical location of swelling
Ⅲ- Histopathological examination of the swelling:
The swelling was surgically removed and sample were fixed in 10% buffered formalin and embedded in paraffin by routine method , sections, 4mm thick were stained with haematocyline and eosine (HE) (Bancroft et al., 1996).
Ⅳ- Treatment of thecases:
According to the characters of the swelling and nature of the affected area, one of the following treatment was used:
A: Surgical excision of the swelling followed by suture of the wound B: Surgical excision of the swelling without suture of the wound
C: Injection of autogenus vaccine, follow up of treated cases for 2 months was obtained and the result was recorded.
D: Auto hemotherapy technique, follow up of treated cases for 2 months was obtained and the result was recorded.
E: Salicylic acid lotion.
The results of the present study are:
1- History and clinical examination revealed that:
The animals were of both sex (38 females and 12 males), and of different ages ranged from 9 months to more than 2 .5 years (37 animals from 9-18 months; 7
animals from 18 months - 2 .5 years; six animals more than 2 .5 years).
The swellings are of different size ranged from small warts less than 10 cm3 up to large size warts reach to 300 cm3 (less than 10 cm3 (39 animals)* 10-30 cm3 (5 animals)* 30-100cm3 (3 animals)* up to 300 cm3 (3 animals).
About 13 animals had one swelling, two animal had two swellings, 10 animals had three swellings, nine animals had four swellings, 10 animals had five swellings, three animals had six swellings and three animals had twenty swellings.
Anatomical distribution of swellings was at the head and neck (51.7%), fore limb (6.6%), hind limb (10.4%), genital and perineal region (8.06%), chest, abdomen and wither (2 3.3%).
2- Histopathological examination:
The results of histopathological changes of the effected skin included a marked hyperkeratosis with downward hyperplasia like finger projection of stratum basale with presence of fibrovascular core, also the result showed hypergranulosis
proliferation of granulocytes) with hydropic degeneration of granulocytes in the stratum granulosum Furthermore; there was marked acanthosis, hyperkeratosis and downward hyperplasia.
3- Treatment of the cases revealed that:
In first group Follow up the cases revealed complete recovery and good healing of the wound in 23 swellings (95.8%) while healing was not completed due to secondary bacterial infection because the owner removes the stitches after only 6 days and wasn’t care about the wound unfortunately.
Recurrence of papilloma were not recorded in any swelling after 6 months.
In second group Follow up of the cases revealed a good wound healing in 31 swelling (88.6 %) which recurrence of the swelling were recorded in 4 swelling (11.4%).
In third group Follow up the cases for 3 months revealed complete regression and disappearance of 72 swellings (8 cases) (90%) affecting Head, Neck, chest, abdomen, forelimb, hind limb. 8 swellings still present without complete regression (10%) affecting trunk, perineal region.
In fourth group Follow up the cases for 3 months revealed complete regression of 32 swellings (55.1%) affecting Head, Neck, abdomen while 2 6 swelling (44.9%) affecting forelimb, hind limb, dewlap, perineal region and trunck still present without complete regression.
In fifth group Follow up for 14 days revealed complete removal of 10 swellings (71.4%) affecting animals less than 18 month of age while 4 swellings (26.6%) in 2 animals more than 2 .5 year.