الفهرس 
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Abstract
The present investigation was conducted in order to evaluate histo-pathological and immuno-histochemical effect of mineral tri-oxide aggregate, bio-dentine and calcium hydroxide on furcation perforation repair. In this study we used six dogs divided into three main equal groups according to post-treatment evaluation period.
group I: 1 week (2 dogs)
group II: 1 month (2 dogs)
group III: 3 months (2 dogs)
Each group was further subdivided into three experimental subgroups according to the treatment protocol. The subgroups included:
Subgroup A: MTA (8 teeth)
Subgroup B: Biodentine (8 teeth)
Subgroup C: CaoH2 (8 teeth)
* Histological evaluation
The following histopathological findings were evaluated:
1- Inflammatory cell count:
It was assessed according to Salman et al 46
2- Hard tissue formation:
It was classified as:
Score 0: absence of new hard tissue formation
Score 1: presence of new hard tissues formation.
Immunohistochemical evaluation:
The immuno-histopathological finding evaluated was IL-6 Immunolabelled cell count.
As regard to Inflammatory cell count : In group I : MTA and Bio-dentine showed high inflammatory cell count while In groups II and III : MTA and Bio-Dentine showed a significant lower mean inflammatory cell count (mild inflammation) than Calcium hydroxide
As regard to new hard tissue formation: In group I: Deposition of new hard tissue was evident in very little samples treated. In groups II and III: MTA and Bio-Dentine showed a significant higher mean prevalence of new hard tissue formation than calcium hydroxide.
As regard to IL-6 Immunolabelled cell count: In groups II and III MTA and Bio-Dentine showed a significant lower mean of IL-6 immunolabelled cells count than Calcium hydroxide.