الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology in the world, it affect 20–30 % of people. NAFL is considered the benign and reversible stage. The severe and irreversible form of NAFLD is the nonalcoholic steatohepatitis (NASH) that include hepatocyte injury, inflammation and degrees of fibrosis in addition to steatosis. The present study were designed to examine the therapeutic effect of silymarin, vitamin D and the combination of both on experimentally induced non-alcoholic fatty liver disease in adult albino rats using biochemical, histopathological, immunohistochemical and ultra-structural parameters. A 30 adult male Sprague-Dawley rats, with average weight ranging between ”200-250” grams were used. The rats were randomly divided into 5 groups 6 rats in each group. group I: basal diet (BD) group, animals were received basal diet and ordinary drinking water. group II: high fat diet (HFD) group, animals were received high fat diet and 20% fructose drinking water for 8 weeks. group III: HFD + Silymarin treatment (HFD+S) group, animals were fed with high fat diet and 20% fructose drinking water for 8 weeks then were fed with high fat diet and 20% fructose drinking water with intra-gastric administration of Silymarin in a dose of 30 mg/kg/day for 4 weeks.