الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Fifty patients with acute ST-segment elevation myocardial infarction were enrolled in this prospective study, (mean age was 58±9 years, 40 male and 10 female), all of them underwent reperfusion thereby at Mansoura Specialized Medical Hospital.
Proper history taking, physical examination, ECG, Echocardiography and full lab including (cardiac enzymes, fasting blood sugar and two hours post prandial blood sugar) were done. Then coronary angiography was performed to 35 patients then short term follow up period for three months was done to detect major adverse cardiac events.
In the present study, there was statistical significant difference among different HbA1c groups as regard CK-MB and troponin, with higher mean peak CK-MB and troponin in-group (3) with statistical significant positive correlation between peak CK-MB and troponin with HbA1c.In the present study, there was statistical significant difference among different HbA1c groups as regard fasting blood sugar and two-hour postprandial blood sugar with higher mean fasting blood sugar and two-hour postprandial blood sugar in-group (3) with statistical significant positive correlation between fasting blood sugar and two-hour postprandial blood sugar with HbA1c.In the present study, there was statistical significant difference among different HbA1c groups as regard lesion type (A, B, C), with higher type A lesion in group (1) and higher type C lesion in group(3).
In the present study, there was statistical significant difference among different HbA1c groups as regard TIMI flow grade in patients who had undergone 1ry PCI, with higher percentage of TIMI 3 in group (1) and higher percentage of TIMI 1 in favor of group (3), this finding goes with the fact that hyperglycemia is associated with higher rate of TIMI 0\1 and lower rate of complete revascularization TIMI 3. In the present study, there no was statistical significant difference among different HbA1c groups as regard major adverse cardiac events. In the present study, we found that diabetes mellitus, hypertension and HbA1c over 6.5% were significant predictor of short-term adverse cardiac events in (univariate regression analysis) but in (multivariate regression) only HbA1c 6.5% was the actual significant independent predictor outcome. Finally, The study showed that admission of higher HbA1c is associated with more severe CAD, higher percentage of TIMI 1 follow, lower rate of complete revascularization (TIMI 3 follow) and higher incidence of mortality.