الفهرس | Only 14 pages are availabe for public view |
Abstract Orthotropic liver transplantation (OLT) became the standard of care for patients with decompensated cirrhosis and for patients with hepatocellular carcinoma. Nowadays 9.6% of total Egyptian liver transplantation surgeries are performed in National Liver Institute & high graft survival rates have been achieved in great part due to the availability of potent immunosuppressive agents. Unfortunately, systemic immunosuppression has rendered the liver recipient susceptible to de novo infections as well as reactivation of preexisting latent infections which occurr during the first month post- OLT especially fungal infections. The most common post transplant fungal infections are Candida infections, which range from superficial oral candidiasis to life threatening invasive blood candidiasis. Recognizing infections in transplant recipients is difficult; clinical signs and symptoms are often not specific and might be muted &fever is a nonspecific symptom. At the same time, differentiating infective from no infective causes requires thorough clinical evaluation, diagnostic procedures, and radiologic imaging for an appropriate diagnosis Given the increased risk and poor outcomes in liver transplant recipients who develop fungal infections, early diagnosis and aggressive antifungal prophylaxis should be considered upfront in high-risk patients & so improve outcomes. The aim of this study was to determine the incidence of Candida infection among liver transplantation recipients in National Liver Institute, evaluate the value of mannan antigen assay in early detection. |