الفهرس 
Obesity, Metabolic Syndrome and Cardiovascular RiskOnly 14 pages are availabe for public view
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Abstract
Atherosclerosis and its clinical manifestations in coronary heart disease, stroke, and peripheral artery disease are the leading cause of morbidity and mortality worldwide .Atherosclerosis is considered to be a chronic inflammatory disease and scientific interest has focussed on the role of cytokines as possible predictor agents for early atherosclerosis and as a therapeutic target for atherosclerosis. As obese patients with nonalcoholic fatty liver disease (NAFLD) are vulnerable to many risk factors for atherosclerosis that related to metabolic syndrome and NASH prevalence in those patients. The extent of inflammation in atherosclerotic or high risk patients as measured by specific biomarkers probably reflects the activity of the disease and therefore may predict the individual’s risk for progression of atherosclerosis.So,the aim of our study was to study the role of serum Eotaxin, in early prediction of atherosclerosis in obese patients with nonalcoholic fatty liver disease (NAFLD). The study included 90 participants 60 of them were obese with NAFLD (cases) recruited from Tanta University Hospitals endocrinology ,diabetes & metabolism outpatient clinics and inpatient wards and cardiology department inpatient wards and outpatient clinic) from December 2014 to June 2017, and 30 participants were age and sex matched healthy subjects (control group). Ethical approval was obtained and each subject gave a written informed consent. The patients were subdivided into 3 groups 30 obese patients with NAFLD without vascular ischaemic complications as non ischaemic obese group , 30 obese patients with NAFLD with vascular ischaemic complications who were patients with CAD in form of recent MI ,unstable angina or stable angina as ischaemic obese group and 30 age and sex matched healthy subjects were included as a control group . Patients with autoimmune diseases or on steroid therapy were excluded as all of that may affect the result of inflammatory cytokines. Also,allergic diseases were excluded as Eotaxin known to be increased in these patients .