الفهرس 
Physiology of HemostasisOnly 14 pages are availabe for public view
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Abstract
Background: The aim of this study was to evaluate the D-Dimer and Protein S in cirrhotic patients with and without ascites.
Methods: Patients with cirrhosis, who were admitted to hospital with decompensation of the liver (as defined by Development of ascites, hepatic encephalopathy) with and without ascites and underwent abdominal-sonography were included in this study. Compensated cirrhotic patients were also included. Laboratory data for computing Child-Pugh classification score, serum albumin, serum bilirubin, international normalized ratio, prothrombin time, transaminases, serum D-Dimer, and serum protein S, complete blood picture were collected for every patient. We tabulated hemostatic concentrations, liver functions tests, and sonogrophy parameters. WE analysed the correlation between D-Dimer, Protein S and each of the individual prognostic scores.
Results: A total of 90 patients with a diagnosis of liver cirrhosis were included in this study in wich 52 have no ascites, 38 patients were found to have ascites. In our study population with liver cirrhosis, we found statistically significance inverse correlations between D-Dimer and liver severity according to child-classification, also between D-Dimer and Protein S, As well as Protein S correlate with liver cirrhosis progression . However, the presence of ascites has and excess effects in occurrence of this two proteins (D-Dimer and protein S).
Conclusion: We observed the inverse relationship between D-Dimer and protein S, and statistically high significance inverse correlations between D-Dimer and liver severity according to Child-Pugh class used in this study among patients with liver cirrhosis, protein S correlate with liver damage severity positively. Although ascites have an additional excess impact on both proteins