الفهرس 
CHRONIC MYELOID LEUKEMIAOnly 14 pages are availabe for public view
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Abstract
Background
Outcome in chronic myeloid leukemia (CML) have improved with tyrosin kinase inhibitor treatment (TKI). Additional chromosomal abnormalities (ACAs) are strongly associated with disease progression but their prognostic impact and influence on treatment response in young adult are yet to be defined. The aim of this study was to analyze the impact of ACAs in Egyptian young adult on response to treatment.
Materials and methods: The data from the Hematology Department and outpatient clinic of Ain Shams University was collected, this observational retrospective study conducted on 99 young adult CML.
Results: ACAS at diagnosis were found in 7.1% (7), 4 patients have achieved molecular response and during treatment ACAS were found in 10 patients4 patients have achieved molecular response and 4 patients were isochromosome 17(iso ch 17) positive, three patients of them didn’t achieve molecular response and shifted to tasigna.
Conclusions: additional research in this population is required to better define the outcome