الفهرس 
H YPOTHYROIDISMOnly 14 pages are availabe for public view
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Abstract
Background: Vitamin D is a fat-soluble vitamin which is predominantly synthesized in the skin, it is considered one of the natural immune modulators and a regulator of various immune-mediated processes. Vitamin D deficiency is a global health problem. Over a billion people worldwide are vitamin D deficient or insufficient. Vitamin D deficiency has been shown to be associated with autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD) and that vitamin D supplementation prevents the onset and/or development of these autoimmune diseases. Aim of the Work: is to assess vitamin D status in some Egyptian patients with autoimmune hypothyroidism proved by assay of TPO in those patients. Materials and Methods: Our study will be conducted on 90 subjects, selected from the outpatient clinic of endocrinology department of Ain Shams University Hospitals and El Mataria Teaching Hospital. They were classified into two main groups: group І: 60 patients with hypothyroidism, [10 Males (16.6%) and 50 Females (83.4%)], their mean ages ± S.D 40.50 ± 11.80 year, group ІІ: 30 subjects as a control group apparently healthy individuals with matched same age and sex. Serum vitamin D was measured using enzyme-linked immunosorbent assay (ELISA) technique. Results: All subjects in our study were submitted to complete history taking emphasizing on symptoms of hypothyroidism as well as excluding other systems disorders, complete clinical examination, laboratory investigations including: Thyroid function (free T3, free T4, TSH), anti-thyroid peroxidase [anti-TPO], Serum 25 (OH) vit D by ELISA. In our study, there was a high significant difference regarding vitamin D level among the studied groups. Conclusion: from the previous results we concluded that: Vitamin D is deficient in hypothyroid patients more than healthy individuals, Vitamin D is more deficient in patients with autoimmune hypothyroidism, Vitamin D serum levels are significantly more decreased in females than males, Low vitamin D may increase the degree of autoimmunity and subsequently increase the prevalence of AITDs.