الفهرس 
Inflammation and end stage renal diseaseOnly 14 pages are availabe for public view
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Abstract
Background: Patients with ESRD have elevated levels of inflammatory mediators including C-reactive protein (CRP),tumour necrosis factor-α (TNF- α), and interleukin-6 (IL-6). Neutrophil to lymphocyte ratio was introduced as a novel inexpensive indicator that reflects the severity and extension of systemic inflammation and atherosclerosis, and predicts adverse clinical outcomes in cardiac and non cardiac disorders including ESRD.
Aim of the study: to evaluate the frequency of subclinical inflammation using neutrophil to lymphocyte ratio (NLR) and to evaluate the relationship between NLR and other biochemical parameters in maintenance hemodialysis patients in comparison to high-sensitivity C-reactive protein (hsCRP).
Methods and results: a cross sectional observational study including 100 clinically stable ESRD patients on regular HD ( mean age 48.25 ± 13.67, 57% were males) , NLR was calculated from complete blood count and hsCRP was recorded for all patients where 8.2 mg/L indicated inflammation. NLR was positively correlated to hsCRP, using ROC curve the best cut off point to detect subclinical inflammation in HD patients was calculated with NLR greater than or equal 1.54, with sensitivity 68.25% and specificity 54%. And by using univariate and multivariate regression analysis NLR was found to be an independent significant predictor of hsCRP and inflammation.