الفهرس 
Vitamin D Physiology And StructureOnly 14 pages are availabe for public view
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Abstract
Introduction: vitamin D Deficiency has been reported in patients with many types of musculoskeletal pain, nonspecific bone pain at different regions of the skeletal system such as leg pain, widespread pain, arthralgia, rib pain and back pain. Vitamin D endocrine system plays potential immune-regulatory roles and to exert an action on the immune system cells, generating anti-inflammatory and immunoregulatory effects in rheumatological diseases.
Aim: to determine the status of vitamin D sufficiency in a sample of patients presenting at rheumatology clinic in a tertiary referral hospital in greater Cairo area and identify its impact on diagnosis and symptomatology of common rheumatological diseases.
Patients and methods: our study included 80 patients who were classified according to different disease groups into 20 Patients with Rheumatoid Arthritis, 20 Patients with Systemic Lupus Erythematosus, 20 Patients with Osteoarthritis and 20 Patients with Miscellaneous Rheumatological Diseases.
Results: our study revealed relation between serum 25 (OH) vitamin D and different rheumatological diseases, Serum 25 (OH) vitamin D recorded the lowest level in the Rheumatoid Arthritis patients followed by Systemic Lupus Erythematosus, Osteoarthritis and Miscellaneous diseases respectively at (P value < 0.05). Moeover, there were statistically significant differences between serum 25 (OH) vitamin D sufficiency groups as regard smoking and corticosteroid therapy.
Conclusion: Knowledge about the potential role of serum 25 (OH) vitamin D made it a fundamental investigation in diagnosis and follow up of rheumatological diseases as it is implicated in pathogenesis and treatment of such diseases.