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Abstract Thromboembolic events in transfusion dependant ß-thalassemic patients are associated with some risk factors as: increased platelets count, splenectomy, and vWFa level. VWF which is used as marker of endothelial dysfunction , could be a risk factor for thrombosis in these patients with specificity of 93.9% and high level indicate poor outcome. Although studies reported that total MPs are increased in thalassemic patients, but in this study monocytic microparticles (cd14) wasn’t increased and no significant difference was found between patients and controls ( p-value > .05). There was a decrease in cd11b level (monocytes activation) in thalassemic patients than controls that may be due to iron overload which cause dysfunction of monocytes. |