الفهرس 
Polycystic ovary syndromeOnly 14 pages are availabe for public view
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Abstract
Summary & Conclusion<
RPL is one of the most frustrating and difficult areas in reproductive
medicine because the etiology is often unknown and there are few evidence -
based diagnostic and treatment strategies. It differs from infertility and classically
refers to occurrence of two or more consecutive losses of clinically diagnosed
pregnancies prior to 20th week of gestation.
Recurrent pregnancy loss in women at different trimesters is associated with
endocrine abnormalities where serum homocysteine levels increase in a different
way from the increased levels in normal healthy pregnant women.
It is the main hazard in pregnancy both for naturally conceived and those
after ART treatment. Intensive researches including immunological and genetic
studies all still in progress to elucidate the etiology of recurrent pregnancy loss.
Chromosomal anomaly, uterine malformation, hypothyroidism, cervical
incompetence, antiphosphlipid syndrome, bacterial infections, and polycystic
ovary syndrome (pcos) are some of etiological factors associated with RPL.
Polycystic ovary syndrome (PCOS) is a common disease among women
in fertile age. It is associated with ovulation disturbances, infertility,
hyperandrogenism, increased abortion rate, obesity, hyperinsulinemia,
hypertension, atherosclerosis and vascular diseases are other problems ascribed
to PCOS.
Homocysteine is a non-protein a-amino acid.It is a homologue of the
amino acid cysteine. A high level of homocysteine in the blood
(hyperhomocysteinemia) makes a person more prone to endothelial cell injury,
which leads to inflammation in the blood vessels, which in turn may lead to athero
genesis, which can result in ischemic injury.Thrombophilia is also an important risk factor for abortion in PCO
patients. In this regard, previous Studies have demonstrated that factor V Leiden
associated thrombophilia, heterozygosity for prothrombin factor mutations, and
homozygosity for methylene tetrahydrofolate reductase gene (MTHFR) mutations
and deficiencies of some proteins, including protein C, protein S, and
antithrombin III, are also associated with pregnancy complications and
miscarriage.
The aim of this study is to assess the relationship between serum
homocystiene level in PCOS women with history of recurrent pregnancy loss.
The present study has carried on 90 non pregnant women in reproductive
period ,their age ranged from 20-35 years they were classified into three groups:
Group1 patients with PCOS and history of recurrent pregnancy loss (30
patients), group 2 patients non PCOS with history of recurrent pregnancy loss (30
patients) and group 3 patients with normal obstetric history non PCOS and
without RPL (control 30 patients).
Assessment of plamsa homocystiene level (Hcy) using ELISA by the aid
of clinical pathology department .
In conclusion, our study found that homocystiene levels are higher in
PCOS women with recurrent pregnancy loss than those non PCOS women .