الفهرس 
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Abstract
Wilms’ tumor gene 1(WT1) was first categorized as a tumor suppressor gene that is inactivated in Wilms’ tumor, On the contrary, oncogenic properties of the gene has been observed in some other neoplasms. It was suggested that WT1, might have a role in cellular differentiation and tumorigenesis in PAs .This work was conducted to investigate the role of angiogenesis in PA and CXPA using CD105 marker which was reported to be specific in tumor angiogenesis and endothelial cell proliferation. Finally, CD1a marker is a member of CD1 antigen-presenting proteins that is important in the anti tumor immune response by presenting lipids rather than peptides to T lymphocytes cells. The present study was conducted on paraffin embedded blocks of 19 cases of PA, 8 cases of CXPA and serial sections stained with Haematoxylin and eosin staining and Immunohistochemical staining The immunohistochemical staining pattern of WT1 in each was assessed in the different cell types of both the normal and neoplastic salivary gland tissues in 5 randomly selected high-power fields (x 400) of different studied sections and percentage of positive cells was scored semi-quantitatively .Meanwhile, CD105 expression was assessed by counting the number of CD105 highlighted vessels in 3 hot spots in high power magnification (X200) and the mean was recorded. -Finally, CD1a-positive dentritic cells were counted in up to five microscopic fields at a final magnification of X200, considering cells present inside the stroma and tumor parenchyma then a mean was recorded. Immunohistochemically, the statistical results revealed significant difference of WT1and CD105 expression and intensity upon comparing PA and CXPA. Meanwhile, no statistical significant difference was found in CD1a- DCD among cases of PA and CXPA.