Author: Merds, Zekrayat Jawad Henidi./ Title: Effect of liraglutide and glutamine aminoacid on proliferation of pancreatic islets of Langerhans and SNAT2 transporter expression in rats with streptozotocin-induced diabetes mellitus /

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العنوان

Effect of liraglutide and glutamine aminoacid on proliferation of pancreatic islets of Langerhans and SNAT2 transporter expression in rats with streptozotocin-induced diabetes mellitus /

المؤلف

Merds, Zekrayat Jawad Henidi.

هيئة الاعداد

مشرف / Zekrayat Jawad Henidi

مشرف / Yasser M. A. Moustafa

مشرف / Norhan M. El-Sayed

مشرف / Sawsan A. Zaitone

الموضوع

Pharmacology & toxicology (Boca Raton, Fla.)

تاريخ النشر

2017.

عدد الصفحات

101 P. :

اللغة

الإنجليزية

الدرجة

ماجستير

التخصص

الصيدلة ، علم السموم والصيدلانيات

تاريخ الإجازة

1/1/2017

مكان الإجازة

جامعة قناة السويس - كلية الصيدلة - الادوية والسموم

الفهرس

Only 14 pages are availabe for public view

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Abstract

Glutamine has a role in regulation of insulin release from pancreatic β-cells. Male rats were allocated in groups, (i) vehicle group, (ii) Streptozotocin-diabetic rats, (iii) Streptozotocin-diabetic + liraglutide (150 μg/kg), (iv) Streptozotocin-diabetic rats + glutamine and (v) Streptozotocin-diabetic rats + liraglutide and glutamine.
Results indicated that treatment with liraglutide and/or glutamine enhanced insulin production and hence glycemic control in diabetic rats with favorable effects on apoptosis markers. Treatment with glutamine and its combination with liraglutide significantly increased pancreatic expression of sodium-dependent neutral aminoacid transporters-2 by approximately 30-35 fold. Addition of glutamine to liraglutide regimen enhances the glycemic control.