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Abstract Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and accompanied by long term damage, dysfunction and failure of various organs. Several studies have shown that glycated albumin (GA) is more reliable DM monitor and a better marker of glycemic control in patients with fluctuating and poorly controlled type 2 DM. Moreover serum GA is not affected by factors that affect hemoglobin metabolism (koga et al., 2015) The Aim of this work was to study the value of serum glycated albumin as a new marker for glycemic control in diabetic children. Subjects and methods: 30 diabetic children were included in the study in addition to 20, sex and age matched apparently healthy children as a control group. All children were subjected to history taking, general examination and laboratory investigations in the form of Hb level and Albumin level in the baseline visit. Plasma glucose both fasting and post prandial, GA and HbA1c measurements were done at baseline, 1st and final follow up visits for all the subjects. Results: GA levels strongly correlated with HbA1c% in diabetic group. The mean GA and HbA1c values were significantly lower in control group than in diabetic group (p<0.001). GA, HbA1c and the ratio decreased significantly within 4weeks, but GA showed a significantly larger decrease than HbA1c. Conclusion: The results of the present prospective study suggest that GA may be a useful marker for assessing short term glycemic changes in pediatric diabetic patients. It may be useful to assess the early improvement in the treatment of diabetes. Recommendations 1-The use of GA for short term glycemic control in diabetic children to avoid complication of hypoglycemic and hyper glycemic complications in children. 2-GA may be better in glycemic control monitoring than HbA1c in diabetic children with anemia, Hemodialysis and haemoglobinopathies. |