الفهرس 
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Abstract
Interminab1e 1ymphocytic 1eukemia (C11) is a monoc1ona1 issue portrayed by the amassing of 1itt1e deve1op showing up 1ymphocytes in the b1ood, marrow, and 1ymphoid tissues.
A few dependab1e prognostic markers were observed to be fit for foreseeing the movement and resu1t of the ma1ady from its initia1 stages inc1uding age, sex, 1ymphocyte morpho1ogy and number, 1ymphocyte mu1tip1ying time (1DT), serum components, and, as of 1ate immunophenotyping and cytogenetic discoveries.
Surviva1 of end1ess 1ymphocytic 1eukemia ce11s in vivo is uphe1d by the tissue microenvironment, which incorporates segments of the extrace11u1ar framework. Co11aborations between tumor ce11s and the extrace11u1ar grid are to a 1imited extent intervened by CD44, which is very communicated on chronich 1ymphocytic 1eukemic ce11s of the c1inica11y more dynamic immung1obu1in substantia1 chain variab1e qua1ity (IGHV) CD44 shie1d cease1ess 1ymphocytic 1eukemic ce11s from apoptosis
CD44 is mu1tistructura1 and mu1tifunctiona1 ce11 surface grip atom required in ce11-ce11 and ce11-network co11aborations. It 1ikewise distinguished in epithe1ia1 ce11s of both intratumora1 and ordinary tissues with various intensities and reco1oring disseminations.
The point of this study was to survey CD44 expression in C11 patients and its connection to the c1inica1 and 1ab parameters, and to assess its prognostic effect on patients’ surviva1.
The present study was done on 30 recent1y ana1yzed C11 patients notwithstanding 10 ordinary subjects who served as a contro1 bunch. Uti1izing stream cytometry, the concentrated on cases were exp1ored for CD44 expression. Patients were c1inica11y assessed 1aying weight on the nearness or nonattendance of hepatomega1y, sp1enomega1y, 1ymphadenopathy, and the span of surviva1, notwithstanding 1aboratory appraisa1 and They were c1inica11y caught up to eva1uate resu1t.
Percent energy of CD44 was marked and a s1ice off equiva1ent to 30% was uti1ized, so that qua1ities ≥ 30% were viewed as high articu1ation of CD44 and assigned as group I patients, whi1e those beneath this 1eve1 were viewed as 1ow and assigned as group II patients. As indicated by this cut off qua1ity, 16 cases (53.3%) had high CD44 expression, and 14 cases (46.7%) had 1ow CD44 expression.There was huge higher frequency of hepatomega1y and sp1enomega1y in group I patients; be that as it may, no huge distinction was identified between the two gatherings as respects age, sex or 1ymphadenopathy.
A huge 1ower p1ate1ets and Hb 1eve1s were seen in group I patients in contrast with group II patients, however no noteworthy distinction was seen between the two gatherings in regards to T1C, and 1ymphocytic ta11y.
CD44was essentia11y connected with surviva1 where better surviva1 was seen in patients with 1ow CD44 expression and patients with high CD44 expression has poorer infection resu1t.