الفهرس 
General scope and epidemiology
Subjects and MethodsOnly 14 pages are availabe for public view
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Abstract
BACKGROUND: Obesity, a worldwide public health
problem, is associated with a number of polymorphisms of
genes involved in its pathogenesis. Thus, this case-control
study aimed to clarify the association between genetic
variations within methylene tetrahydrofolate reductase
(MTHFR) and ATP-binding cassette transporter A1 (ABCA1)
genes and obesity in an Egyptian population of children and
adolescents.
METHODS: Anthropometric parameters along with lipid
profile were measured, in addition to genotyping of MTHFR
C677T and ABCA1 G656A polymorphisms using allelic
discrimination assay in 51 obese and 30 normal weight age
and sex matched child and adolescent.
RESULTS: Compared to control, obese subjects showed a
significant difference in the presence of C677T polymorphism,
but not G656A. C677T polymorphism increased susceptibility
to obesity under all genetic models while G656A
polymorphism failed to show any association with the
predisposition of developing obesity. SNP-SNP interaction
showed that CT/AG carriers are at a higher risk to develop
obesity compared to wild type carriers.
CONCLUSION: MTHFR C677T polymorphism could
contribute to the development of obesity while there is no
association related ABCA1 G656A polymorphism with simple
obesity among Egyptian children and adolescents. Joint
effects of the two genes revealed that the carriers of the mutant
alleles of both MTHFR and ABCA1 are at high risk to develop
obesity.