الفهرس 
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Abstract
Striae distensae (SD) are a common form of linear atrophic dermal scars covered with flat atrophic epidermis that appear on the skin as erythematous, violaceous, or hypopigmented linear striations. Striae distensae is diagnosed clinically by their appearance as atrophied lines. There are two forms of SD; striae rubra and striae alba. The majority of topical products did not have any peer-reviewed evidence to support their use on SD. Overall, there is limited evidence for the efficacy of topical therapy for the treatment of SD and most of the evidence suggests that there is limited proof of the efficacy of the commonly available topical preventative agents. The aim of this study was to compare the efficacy and the safety of the use of ablative fractional CO2 laser therapy and carbon dioxide gas injection in treatment of both striae destines. The present study is a randomized clinical trial, carried on sixty four female patients (Fitzpatrick skin types II–III) with moderate to severe striae collected from February 2016 to March 2018. They were selected from the out patients clinic of dermatology, andrology and STD department of Mansoura University Hospital. Results: Most of striae were observed in abdomen (34.1%), followed by lower limb (24.8%), upper limb (20.9%), back (14%) and breast (6.2%). There was a significant improvement in surface areas after treatment with CO2 laser as well as with CO2 gas injection. No significant differences were found in improvement after last session between treatment modalities in cases with striae rubra. Excellent improvement was significantly associated with striae alba treated with CO2 laser, while moderate improvement was significantly associated with striae alba treated with CO2 gas injection. Conclusion: Ablative resurfacing CO2 laser and carboxytherapy are not a new technique within medical practice but both are considered new treatment modalities in dermatology, mostly in treatment of scares and striae distensae. Ablative resurfacing CO2 laser is believed to be a powerful and efficient available laser. It can generate very high average power preferentially absorbed by intracellular and extracellular water creating rapid heating and vaporization of tissue and thermal injury below the vaporization zone induces desiccation and collagen shrinkage, which serves as a scaffold for the formation and deposition of new collagen.