الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
Weight loss after laparoscopic sleeve gastrectomy (LSG) has been mainly attributed to the restriction of gastric volume; however; other factors may contribute to weight loss after LSG. This study aimed to investigate the correlation between the number of ghrelin-secreting cells in the gastric fundus and excess weight loss (EWL) at 12 months after LSG.The surface area of the gastric fundus was measured postoperatively in square centimetre. Histopathologic examination of the gastric fundus was made to estimate the number of ghrelin-secreting cells per square centimetre then was multiplied by the surface area of the fundus to calculate the total number of ghrelin-secreting cells in the fundus. The number of ghrelin-secreting cells was correlated with EWL and BMI at 12 months postoperatively.The present study included 39 patients of a mean age of 33.7 years. The mean %EWL at 12 months was 59.7 ± 12.7. The mean total number of ghrelin-producing cells in the gastric fundus was 26,228.4 ± 16,995.3. The total number of ghrelin secreting cells had a weak positive correlation with BMI at 12 months (r = 0.2891, p = 0.07), and weak negative correlation with %EWL (r = − 0.1592, p = 0.33).There was a weak correlation between the total number of ghrelin-producing cells in the gastric fundus and plasma ghrelin levels with EWL after LSG.ConclusionThere was weak correlation between the total number of ghrelin producing cells in the gastric fundus and plasma ghrelin levels with excess weight loss after LSG. This weak correlation implies that the role of ghrelin in weight loss after LSG is limited and that minimizing the gastric capacity through sleeve resection is the main cause of weight loss postoperatively.