الفهرس 
Chronic kidney disease
Subjects and MethodsOnly 14 pages are availabe for public view
 |  | from | 152 |  |  |
| | | from | 152 | | |
Abstract
Aim: This study was designed to assess the relationship
between serum levels of anti-Müllerian hormone and 25-
hydroxy vitamin D in chronic kidney disease male patients.
Methods: Serum 25-hydroxy vitamin D and anti-Müllerian
hormone along with follicle stimulating hormone, luteinizing
hormone, prolactin, total testosterone and estradiol were
assayed in 59 patients with different stages of chronic kidney
disease and 21 healthy participants.
Results: Compared to controls, serum levels of anti-Müllerian
hormone and 25-hydroxy vitamin D were significantly
decreased in patients with chronic kidney disease. The
decreased anti-Müllerian hormone level correlated positively
with estimated glomerular filtration rate and serum levels of
testosterone and 25-hydroxy vitamin D. Meanwhile, it was
negatively correlated with age and serum levels of urea,
creatinine, follicle stimulating hormone, luteinizing hormone
and prolactin. 25-hydroxy vitamin D and luteinizing hormone
explained the 65.9% variability of anti-Müllerian hormone in a
multiple linear regression model. However, anti-Müllerian
hormone in crude correlation was more strongly associated
with serum 25-hydroxy vitamin D than luteinizing hormone.
Conclusion: serum level of 25-hydroxy vitamin D might be a
determinant factor of anti-Müllerian hormone level and their
relationship might explain in part the dysfunction of Sertoli
cells and the impaired testicular functions in chronic kidney
disease male patients.