الفهرس 
introduction and aim of the workOnly 14 pages are availabe for public view
 |  | from | 324 |  |  |
| | | from | 324 | | |
Abstract
Introduction: The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. This significant health care problem lacks effective therapy. The ideal wound dressing is resistant to external forces and pathogens.It reduces patient discomfort, and achieves good cosmetic results.
Aim of the work: was to compare the effect of silver nanoparticles versus silver sulfadiazine on diabetic wound healing in adult albino rat.
Material & Methods: Fifty adults female albino rats were included. The animals were divided into four groups. group I (control).group II (untreated diabetic wound): which included 15 rats, subdivided into three subgroups. specimens obtained on the same day,7 and 15 days of wound excision.
GroupIII:which included 10 rats divided into 2 subgroups.In which silver sulfadiazine cream was applied on the wound daily for 7 and 15 days after excision.
GroupIV: which included 10 rats divided into 2 subgroups. In which nanosilver-ointment was applied on the wound daily for 7 and 15 days after excision.
At the end of the experiment, the specimens were taken and processed for immunohistochemical and histological studies. Morphometric and statistical studies were carried out.
Results:Examination of skin sections of nanosilver treated group revealed continuous epidermis with differentiated keratinocytes with proliferating basal layer .The dermis showed increased collagen deposition ,decreased p53 and increased VEGF expression compared to SSD treated group.
Conclusion: Silver nanoparticles could be more effective than silver sulfadiazine in treatment of diabetic wound.