الفهرس 
EpidemiologyOnly 14 pages are availabe for public view
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Abstract
The present study included 54 patients with the diagnosis of nasopharyngeal carcinoma divided into 2 groups, group A was treated using 3D conformal radiotherapy (CRT) whereas group B was treated using Intensity modulated radiation therapy (IMRT). The aim of this study was to evaluate and compare both techniques as regard their efficacy on tumor response, local control, overall survival and progression free and treatment related toxicity between both techniques. Chemotherapy was offered to the two groups in the form of given concurrently with radiation therapy and as adjuvant treatment. The median age in 3DCRT and IMRT 44.9 and 49.9 years respectively.
The male to female ratio was 3:1. Staging was corrected according to the AJCC 2002 staging system, there were more T3 and T4 patients in group A than in group B (36.7 % and 6.7% versus 20.8% and 12.5%) , also the nodal status was more advanced in the 3D conformal arm (group A). Patients were assessed for treatment related toxicity using the European Organization for research and treatment of cancer, the Radiation Oncology group (EORTC/RTOG).Toxicity was divided into acute toxicity during radiation therapy, chemotherapy and late toxicity that occurred at least 90 days post-treatment. In general, acute toxicity was tolerable and complete healing was the rule. As a whole, group A showed a higher toxicity profile as compared to group B. IMRT was able to decrease xerostomia and spare at least part of the parotid gland excretory function which was shown in the salivary gland scintigraphy.
Results of the dosimetric comparison between both techniques showed that IMRT had a better tumor coverage and conformity index. Homogeneity index was similar in the two groups. Also, doses received by the risk structures, particularly parotids, was significantly less in the IMRT plans than those of 3D-CRT.