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العنوان
β-Thalassemia Major: Multidisplinary Interplay of Protein Chaperone (heat shock protein 72), SIRT-1and DNA Damage in Relation to Vascular Complications /
المؤلف
Ibrahim ,Hoda Ali Mohamed.
هيئة الاعداد
باحث / هدى على محمد ابراهيم
مشرف / سامية عبد الحميد الدرديرى
مشرف / منال محمد البطش
مشرف / سها سعيد زكريا
الموضوع
Medical Biochemistry.
تاريخ النشر
2018.
عدد الصفحات
p 236. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكيمياء الحيوية (الطبية)
تاريخ الإجازة
24/3/2018
مكان الإجازة
جامعة طنطا - كلية الطب - Medical Biochemistry
الفهرس
Only 14 pages are availabe for public view

from 273

from 273

Abstract

In regularly transfused patients, iron overload is due to breakdown of red blood cell (7). Iron overload in patients with β- thalassemia major lead to alterations in the arterial structures and the thickness of the carotid arteries. In Addition, It was noted that Carotid Thickness is Positively Correlated with Age, Hemoglobin, ferritin and Atherogenic index of plasma (AIP) in these patients. As a result, coronary artery diseases (CAD) is a quite common cardiovascular complication in thalassemics. Patients on a regular transfusion regimen progressively develop clinical manifestations of iron overload associated with heart dysfunction and left ventricular failure if inadequately chelated.