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Abstract Firstly, great thanks and praise be to ALLAH, the beneficent and the most merciful for indefinite blessing. I wish to express my sincere gratitude and appreciation to Prof. Dr. Amro Hanora, professor of Microbiology & Immunology, faculty of pharmacy at Suez Canal University for granting me the favor working under his supervision and for his continuous guidance, fruitful advice & encouragement throughout this work. I want to express my deeply grateful to Prof. Dr. Abeer Boseila Professor of virology, National Organization for Drug Control and Research, for her kind supervision, enforcement, valuable efforts and advice throughout the work. I would like to express my deep thanks to Dr. Samar Solyman Lecturer of Microbiology &Immunology, faculty of pharmacy at Suez Canal University for her advices and valuable efforts. I would like to thank Dr. Noha Mohamed Lecturer of biophysics, faculty of Science at Cairo University for her generous help in preparing Nano gold particles |