الفهرس 
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Abstract
Psoriasis is a multifactorial chronic inflammatory, recurrent, immune mediated disease affects primarily the skin and/or joints and is characterized by keratinocyte hyperproliferation.
The pathogenesis of psoriasis is complex and the exact mechanism remains elusive. The disease is thought to result from a combination of genetic, epigenetic, and environmental influences.
It is likely that an intrinsic alteration in epidermal keratinocytes plays a very important role in disease expression.
Syndecan-1 is a membrane heparan sulfate proteoglycan expressed over the entire surface of the keratinocyte, involved in numerous processes such as cellular growth, differentiation,proliferation, adhesion, inflammation, wound healing and migration among others.
A role of syndecan-1 in epidermal cell proliferation and migration is under extensive research.
Ultraviolet (UV) irradiation of wavelengths between 280 and 320 nm (UV-B) is a safe and effective treatment for a variety of inflammatory skin diseases including psoriasis. Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB in psoriasis is not well understood.
This study was done to clarify the role of syndecan-1 in the pathogenesis of Psoriasis vulgaris and to detect the effect of narrow band (UVB 311) on their tissue level.
The study included 20 psoriatic patients, and 20 healthy volunteers serving as control group. All patients received 36 sessions of phototherapy (in the form of NB-UVB).
The results of the present study showed significant difference between cases & controls as regards syndecan-1. In addition there was significant decrease in its level after treatment with NB-UVB.
A negative correlation between the Expression of Syndecan-1 in Psoriatic Epidermis before Phototherapy and Psoriasis Areas and Severity Index (PASI) was found.
Finally, the present study concluded that Syndecan-1 may play a role in the pathogenesis of psoriasis. Moreover, the significant decrease in its level after treatment with NB-UVB may be one of the therapeutic mechanisms of NB-UVB in psoriasis.
Summary
Psoriasis is a multifactorial chronic inflammatory, recurrent, immune mediated disease affects primarily the skin and/or joints and is characterized by keratinocyte hyperproliferation.
The pathogenesis of psoriasis is complex and the exact mechanism remains elusive. The disease is thought to result from a combination of genetic, epigenetic, and environmental influences.
It is likely that an intrinsic alteration in epidermal keratinocytes plays a very important role in disease expression.
Syndecan-1 is a membrane heparan sulfate proteoglycan expressed over the entire surface of the keratinocyte, involved in numerous processes such as cellular growth, differentiation,proliferation, adhesion, inflammation, wound healing and migration among others.
A role of syndecan-1 in epidermal cell proliferation and migration is under extensive research.
Ultraviolet (UV) irradiation of wavelengths between 280 and 320 nm (UV-B) is a safe and effective treatment for a variety of inflammatory skin diseases including psoriasis. Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB in psoriasis is not well understood.
This study was done to clarify the role of syndecan-1 in the pathogenesis of Psoriasis vulgaris and to detect the effect of narrow band (UVB 311) on their tissue level.
The study included 20 psoriatic patients, and 20 healthy volunteers serving as control group. All patients received 36 sessions of phototherapy (in the form of NB-UVB).
The results of the present study showed significant difference between cases & controls as regards syndecan-1. In addition there was significant decrease in its level after treatment with NB-UVB.
A negative correlation between the Expression of Syndecan-1 in Psoriatic Epidermis before Phototherapy and Psoriasis Areas and Severity Index (PASI) was found.
Finally, the present study concluded that Syndecan-1 may play a role in the pathogenesis of psoriasis. Moreover, the significant decrease in its level after treatment with NB-UVB may be one of the therapeutic mechanisms of NB-UVB in psoriasis.