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Abstract Summary Rheumatic fever is an illness that occurs following a streptococcus infection and predominantly affects children. Symptoms include fever, arthralgia, nausea and vomiting. RF can cause long-lasting effects in the skin, joints, heart, and brain. RF and RHD represent the main cause of death and disability among school children in the developing countries. However, it is a recurrent disease that can usually be prevented. ASOT is a blood test to measure antibodies against streptolysin O, a substance produced by GAS bacteria. The ASO antibody may be found in the blood for weeks or months after the streptococcal infection has gone away. Ischaemia-modified albumin is a new marker for tissue ischaemia . It has been proposed that reactive oxygen species generated during ischaemia results in ischaemia-modified albumin formation. Ischaemia-modified albumin is accepted as a marker of oxidative stress. Recently, elevated ischaemia-modified albumin levels have been reported in various clinical conditions such as ischaemia, inflammation, and oxidative stress. Furthermore, increased oxidative stress has been shown in acute rheumatic fever and heart valve disease. The aim of the work was to measure the level of ischemia modified albumin in sera of families with a case of rheumatic fever and / or rheumatic heart diseases whatever their presentation . More over, the level of ischemia modified albumin may give us an. |