الفهرس 
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Abstract
Hyperemesis gravidarum (HG) is the most severe form of nausea and vomiting of pregnancy that affects approximately 0.3-2 % of all pregnant women. It typically occurs between the 4th and the 10th week of gestation. A number of risk factors associated with hyperemesis have been reported, including history of hyperemesis gravidarum in a previous pregnancy, family history of severe nausea/vomiting in pregnancy, nulliparity, low maternal age, and psychiatric conditions .Although the exact etiology and pathophysiology of HG is not completely known, it is currently accepted that HG is a multifactorial disorder of pregnancy resulting from the combination of various unrelated conditions such as genetic, environmental, hormonal and psychiatric. Many theories suggest that the cause of HG may have psychiatric bases or may be associated with psychosocial risk factors.
This work was designed to study the correlation of some psychosocial risk factors in hyperemesis gravidarum patients and their relation to some hormonal changes.
The patients were recruited from El-Shatby Maternity University Hospital. All patients (n=50) underwent complete history taking, a comprehensive medical and obstetric examination, ultrasound examination to confirm the intrauterine pregnancy, gestational age and to exclude any relevant obstetric pathology.
Laboratory investigations were carried out including prolactin (PRL), thyroid hormonal profile (TSH, free T3, freeT4) and free β-HCG. Also a psychometric study was conducted in the form of the Arabic version of Minnesota Multiphasic Personality Inventory (MMPI-2).
Our results showed that The cases were mainly primigravida , from urban areas and highly educated (graduate from high school or college), despite that the majority were house wives. Psychological risk factors were assessed by applying the MMPI-2 which showed that most of the cases had severe hypochondriasis, severe depression, severe hysteria, severe psychopathic deviate, severe paranoia, and severe psychasthenia, and severe social introversion while schizophrenia, , and hypo-mania were moderate in most of the studied cases. According to validity scales; most of the cases had low lie scale, low K-scale and moderate F-scale.
Correlation between levels of hormones (Prolactin-βHCG- TSH- Free T3-FreeT4) and MMPI-2 scales was done revealing no statistical significant relation between β-HCG and prolactin levels and scales of MMPI-2 in the studied cases. While there was a significant positive correlation between increase in level of TSH and severity of depression (p=0.032), hysteria (p=0.027) and psychopathic Deviate (p=0.04) in our studied cases. Also there was a significant positive correlation between increase in level of free T3 and severity of F –scale (p=0.021) in the studied cases. And a significant positive correlation was found also between increase in level of free T4 and severity of psychasthenia (p=0.033) in the studied cases.