الفهرس 
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Abstract
Background: hepatitis B is a major global health problem and a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). Hepatitis B virus belongs to the hepadnaviridae class of viruses.
Aim of the Work: to estimate the non-responder rates to the hepatitis B vaccine, to identify possible risk factors of non-response (to determine the need for revaccination and to guide for post-exposure prophylaxis).
Patients and Methods: this study included one hundred healthcare workers at Ain-Shams University Hospitals from different departments after taking informed consents to participate in the study. The study group included all healthcare workers who are currently subjected to HB vaccine standard schedule. The work was performed in-between October 2017 till May 2018.
Results: the mean age of candidates was 34.8±9.0 years with 38% of them were males and 62% were females. About 22% of candidates were smokers, 14% were diabetic and 33% were hypertensive. In our study, the mean HBsAb titer among candidates was 307.9±264.2 IU/mL. It was found that 12% of candidates were non-responders with HBsAB titer < 10 IU/mL. On the other hand, 88% of them were responders with HBsAb titer 10-99 and 100-1000 in 24% and 64% of candidates, respectively.
Conclusion: the non-responder rate to the hepatitis B vaccine (non-significant HBsAbs titer) was 12%. On the other hand, 88% of them were responders with HBsAbs titer 10-99 and 100-1000 in 24% and 64% of candidates, respectively.