الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: Obstetric hemorrhage is the leading cause of maternal morbidity and mortality. Caesarean section (CS) rates have increased to 25 to 30 % in many areas of the world. Tranexamic acid is a synthetic derivative of the amino acid lysine that exerts its antifibrinolytic effect through the reversible blockade of the lysine binding sites on plasminogen molecules. Also TXA may enhance the effectiveness of patient’s own hemostatic mechanism.
Aims: This study aims to assess the efficacy of preoperative administration of TXA in reducing intraoperative and postoperative blood loss in women undergoing primary cesarean section
Methodology: The current study was conducted in Obstetrics and Gynecology department, Ain Shams maternity hospital in the period from May 2017 to January 2018. The study was conducted on 200 patients divided in to study group= 100 and control group =100. The study group was subjected to 1 gram of tranexamic acid given slowly intravenous infusion 15-20 minutes before skin incision. After the delivery of baby 10 IU of oxytocin was given in a 500 ml Ringer lactate infusion.
Results: In the result of the current study a statistically significant decrease in HCT and hemoglobin level has been noticed in group A (placebo group) compared to group B (TXA group). Blood loss during operation, Towel weight gain and pads weight gain were significantly increased in group A compared to group B.
Conclusion and Recommendations: Further trials that include emergency sections and patients at higher risk of PPH might provide more evidence for the efficacy of tranexamic acid in reducing PPH. Further studies are needed to assess the possibility of use of tranexamic acid for management of intrapartum and postpartum hemorrhage.