الفهرس 
Acute Myeloid LeukemiaOnly 14 pages are availabe for public view
 |  | from | 244 |  |  |
| | | from | 244 | | |
Abstract
Myeloid derived suppressor cells (MDSCs) are a diverse population of hematopoietic precursors with the ability to affect host immunity. They have been revealed to be upregulated in chronic inflammatory circumstances and cancer. Limited knowledge is available on myeloid derived suppressor cells of rat origin. The exact role of MDSCs in benzene-induced acute myeloid leukemia has not yet been effectively studied.
On the other hand, medicinal plants are important medical systems that have persevered in developing countries. Some important anticancer agents are still extracted from plants as they cannot be manufactured chemically due to their complex structures. Moringa Oleifera (MO), one of the best known and most widely distributed small native tree, has been studied as a potential therapeutic agent that has anti-cancer, anti-oxidant and anti-inflammatory activities.
Doxorubicin hydrochloride (DOX) has proved to have potential therapeutic responses in acute myeloid leukemia. The objective of this study is to evaluate the therapeutic action of Moringa Oleifera leaves extract versus DOX on the MDSCs in benzene-induced acute myeloid leukemia.To that goal 96 young adult male albino rats 150-180 gm were allotted into two major groups, control and experimental where each was further divided into 4 sub-groups. The control group comprised normal CONTROL, DOX, MO and DOX+MO while the experimental one included AML, AML/DOX, AML/MO and AML/ DOX+MO.
Total leucocyte count, flow cytometry for CD11bc+/His48+ MDSCs were assessed in peripheral blood. Also, histological sections in blood, spleen and liver were studied in all groups.
Results of the current study confirmed that Moringa Oleifera leaves extract seems to be most promising in overcoming doxorubicin side effects and decreasing myeloid derived suppressor cells in benzene-induced acute myeloid leukemia, thus providing a novel insight into the application of Moringa Oleifera-based treatments.