الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acute kidney injury is a complex clinical disorder and continues to be associated with poor outcomes. It is frequently seen in hospitalized patients, especially in critically ill pediatrics.Serum creatinine increases with AKI, and is currently the primary diagnostic test of AKI. Lack of specificity, sensitivity and slow response to alterations in disease severity or treatment are primary reasons why SCr is an unsatisfactory biomarker for renal disease, especially in AKI as SCr levels change with factors unrelated to renal disease, such as age, gender, diet, muscle mass, muscle metabolism, exercise and hydration status. Creatinine levels are also influenced by certain drugs . Furthermore SCr concentrations may not change until approximately 50 % of kidney function has been lost. This makes SCr a poor diagnostic marker for AKI. So new biomarkers have appeared for early prediction of AKI. Among various kinds of these markers, growing evidence showed that KIM-1 performed significant superiority in early detection of AKI than others, especially within 24 hours, before serum creatinine increases, which made it possible to conduct prevention or treatment strategies at a very early stage of AKI
KIM-1 is expressed on the apical surface of proximal tubule cells as a response to injury, and its expression does not disappear until the damage is totally resolved.Aim of the work To evaluate urinary KIM-1 level as a biomarker for early detection of acute kidney injury (AKI) in critically ill pediatric patients.ubjects and methodsThis Prospective case control study was conducted on 25 critically ill children of both sex admitted to PICU of Benha children Hospital and Benha University Hospital and 15 healthy control group of both sex.