الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Skin is a soft tissue that forms about 8% of the total body mass and covers the entire surface area. It is a self-repairing, self-renewing organ in the body. It considered an important barrier from the outer environment to the inner environment. It is also important for temperature regulation, fluid maintenance and sensory control (Baroni et al., 2012).
Diabetes Mellitus often simply referred to as diabetes; is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because its cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger) (Wild et al., 2004).
About 387 million people have diabetes in the world with more than 37 million people in the MENA region; by 2035, this number will rise to 68 million. In Egypt alone, there were over 7.5 million cases of diabetes (20-79 year) already affected in 2014, with the expectation of 13.1 million in 2035 (Guariguata et al., 2014).
Impaired wound healing is a common complication of diabetes mellitus with a major morbidity that leads to pain and severely affects patient’s quality of life (Becker et al., 2012). Diabetic wounds are characterized by impaired angiogenesis, occlusion of blood vessels within the wound bed, and decreased collagen production (Brem and Tomic-Canic, 2007). These wounds are chronic and typically show abnormal healing that is characterized by persistent inflammation, copious exudate, hypergranulation and increased bacterial load (Falanga, 2005).
Various approaches have been developed for diabetic wound healing, but most of these approaches have centered on one facet of wound healing, such as inflammation or growth factors (Hong and Park, 2012). With a multifactorial etiology, therapy that focuses on one facet has limited therapeutic efficacy (Yang et al., 2011).
This study aimed to assess and compare the role of bone-marrow-derived mononuclear cells and insulin in wound healing in adult male diabetic albino rats.
One hundred and seventeen (117) animals were included in this study. Thirteen (13) were used as donor rats for obtaining BM-MNCs. One hundred and four (104) adult male albino rats weighing 150 – 250 g were divided randomly into 8 equal groups, thirteen rats per group. Diabetes induction was done in five groups (Groups B, C, D, E and F), each animal received a single intraperitoneal dose of 40 mg/kg streptozotocin.