الفهرس 
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Abstract
The present study was designed to investigate the adverse effect of Bisoprolol and protective effect of Vitamin E and To Show the result of the combination between Bisorprolol and Vit. E on hepatic and renal disturbance induced in rats by Bisorprolol.
Experimental design:
After one week of acclimatization, eighty rats randomly allocated into 4 equal groups, each of 20 rats.
The 1st group:
Rats in this group were not medicated and left as control and received Nacl as avehicle.
The 2nd group (VE):
Rats in this group treated with vitamin E (1.8mg/kg b.wt. once daily) per os for Successive 21 days.
The 3rd group (B):
Rats in this group treated orally with Bisoprolol (1.8mg/kg b.wt. once daily) for successive 21 days as standard.