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Abstract Pre-eclampsia is a syndrome diagnosed by hypertension and proteinuria after 20 weeks of gestation, affects 5–10% of all pregnancies and remains a leading cause of maternal and fetal morbidity and mortality. Based on clinical presentation, pre-eclampsia is considered as a late pregnancy disorder, but the molecular events leading to its onset seem to occur early in pregnancy. Maternal symptoms of preeclampsia are considered consequences of placental pathology associated with poor placental perfusion, inflammation and ischemia / hypoxia and trophoblast damage. This work was designed to study the serum level of Amyloid A in preeclamptic and normotensive pregnant women at third trimester and to correlate level of Amyloid A with severity of pre-eclampsia. The patients were recruited from El-Shatby Maternity University Hospital. They were divided into three groups, group (I): twenty five normal pregnant women, group (II): twenty five mild preeclamptic patients and group (III): twenty five severe preeclamptic patients. All patients (n=75) underwent complete history taking, clinical examination, ultrasound examination for fetal biometry, mean gestational age, amount of liquor and Doppler US. Laboratory investigations were carried out including complete blood count, liver function tests, renal function tests, and complete urine analysis with albumin in urine and serum level of maternal SAA. The results showed that there was no statistical significant difference as regards age, BMI, gestational age and gravidity& parity. Severe preeclamptic group had significantly higher number and percentage of IUGR with abnormal Doppler than normal group but there was no statistical significant difference between mild preeclamptic and normal group. The mean for maternal serum level of Amyloid A in severe preeclamptic group was significantly high in comparison to normotensive group and mild preeclamptic group. Also, there was statistically significant difference mild preeclamptic groups and normotensive groups. There was no correlation and statistically significant difference between SAA levels and systolic blood pressure or diastolic blood pressure or 24 hour urine protein in severe preeclamptic group. There was no correlation and statistically significant difference between SAA levels and HELLP syndrome or US findings or UA Doppler in severe preeclamptic group |