الفهرس 
Acknowledgement
Atrial fibrillation and cardiac chamber remodelingOnly 14 pages are availabe for public view
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Abstract
After successful pulmonary vein isolation for atrial fibrillation, the left atrium undergoes reverse remodeling. However, few studies have directly studied pulmonary vein remodeling and focused on whether pre PVI-PV conditions could predict outcome of the procedure.Hypothesis We hypothesize that: A) post PVI, in addition to LA remodeling the PVs undergo a parallel degree of remodeling and B) that PV characteristics pre PVI can be used to identify patients more likely to sustain normal sinus rhythm.MethodsPatients (100) scheduled for PVI had a cardiovascular magnetic resonance imaging before and 6±3 months following PVI. PV cross sectional areas within 0.5 cm of the ostium and LA volumes were measured. Patients were categorized as responders (R) or non-responders (NR), based on two separate 14-day Holter monitoring.Results:PVs CSA were significantly reduced post procedure in both groups, R, (233±53 to 192±52 mm2, p<0.001) and NR (241±54 to 207±44 mm2, p<0.001), however, the difference between R and NR post PVI was not significant, (192±52 mm2 to 207± 44mm2, p=0.19). Reduction in PVs CSAs post procedure moderately correlated with the 3D LA volume reduction, (R= 0.48, p <0.001).None of the PV CSA related parameters used showed a direct significant relation regarding prediction of maintenance of NSR at 6 months (p value 0.05).Topological analysis of the available data revealed a promising theory suggesting that many factors and conditions should be put in harmony pre-PVI and kept at certain ranges post PVI in order to achieve a better response.