الفهرس 
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Abstract
Non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) are two very common diseases in the general population. Irritable bowel syndrome is defined as functional gastrointestinal disorder characterized by chronic abdominal pain and changed bowel habits in the absence of an overtly identifiable cause. Non- Alcholic fatty liver is defined as Fat accumulation in the liver in the absence of specific causes of hepatic steatosis, such as alcohol consumption, with or without liver inflammation and its consequences.
Its prevalence about 20% of general population. The objective of our study is to demonstrate that there is relationship between IBS and existence of NAFLD and metabolic diseases. In our study, 100 patient were included from outpatient and inpatient of al-Rajhi hospital, Assuit university who were diagnosed as IBS. One hundred patients were diagnosed as IBS by presence of chronic abdominal pain, constipation, diarrhea or alternating bowel habit constipation and diarrhea, abnormal stool passage, bloating or feeling of abdominal distension. They were included in the study and distributed as 49% males and 51% females. The mean of age ± SD was 47±12 years and 74% of them had NAFLD. The collected data included demographic characteristics of the patients as age, sex and associated comorbidities and clinical presentation of them.
Routine laboratory investigations ALT, AST, rondom blood glucose and hepatitis markers were done to all patients. All patients were evaluated with abdominal ultrasonography.
By evaluation of patients in our study 100% of them IBS, 32% had diabetes mellitus, 69% were obese. By abdominal ultrasound 74% of patients had NAFLD. In this study, IBS severity grading was divided into mild 42%, moderate 43% and sever 15% and the grades of NAFLD were mild (I) among 80% of patients, and moderate/ sever (II) among 20%. Also, in the current study there is significant correlation between tobacco smoking (P value 0.011) , diabetes mellitus (P value 0.009) and IBS severity. On the contrary there is no significant correlation between BMI and IBS severity. Finally, we found that there is significant correlation between IBS severity and NAFLD severity specially ( moderate / sever )( P value 0.023) grading of NAFLD. Conclusion and Recommendations Based on the current study, we found that patients with IBS had higher frequency of NAFLD. Also, there is significant correlation between IBS severity and NAFLD severity. So, patients with IBS should be frequently monitored to assess the presence of NAFLD by: Frequent clinical evaluation Abdominal ultrasonography Lipid profile and liver function if needed.