الفهرس 
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Abstract
This study aimed at assessing knowledge of type 2 diabetic patients on adherence to therapeutic regimen and examining the effect of instructional program on knowledge regarding adherence to therapeutic regiment among type 2 diabetic patients. Research design: A quasi-experimental design. Setting; this study was carried out at diabetic out-patient clinic in Medical Specialized Hospital affiliated to Mansoura University. Sample; random sample of 53 patients was selected. Tool;a structured interview sheet which included: part I) Socio-demographic characteristics; part II) Medical health profile; part III) Assess patient’s knowledge regarding diabetes mellitus; and part IV) Adherencing to therapeutic regimen which included: 1. Morisky medication adherence scale; 2. Health belief model; and 3. Glycosylated hemoglobin test. Results; it was illustrated that 73.6% of the studied sample were females; 32.1% were illiterate and 79.2% belonged low socioeconomic level. Regarding the knowledge, 84.9% of the studied sample had satisfactory score level after applying the program, 98.1% of them had satisfactory beliefs after applying the program. And, 58.5% had high score level of adherence after applying the program. The mean ±SD of glcosylated hemoglobin of the subjects was decreased significantly from 9.5±1.7 to 7.9±1.2 after applying the program. Conclusion; improving diabetic patients’ knowledge regarding type 2 diabetes mellitus wasvery important for improving adherence to the therapeutic regimen. Recommendations; Developing instructional plan based on issues related todiabetic regimen and personel perceptions that militate against adherence.