الفهرس 
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Abstract
The present study was carried out to evaluate the efficacy of bacitracin (400 mg/gallon drinking water), phytobiotic (0.3ml/liter drinking water), Synbiotic (20 mg/bird) and combination of phytobiotic with Synbiotic controlling Clostridium perfringens infection beside their effect on body performance as well as study the effects of infections and used substance on some hematological parameters, and their histopathological effects. This research was held on Ninety, one day-old unsexed Ross broiler chicks, divided into 6 equal groups.
Clinical symptoms, Mortality rate and Lesion Scores: Experimentally infected with Cl. Perfringens showed significant increase in body weight, weight gain and improved in feed conversion rate. Infected broiler treated with Phytobiotic and synbiotic together in tested dose showed significant decrease in body weight and weight gain at the end of the 1st week post treatment associated with insignificant decrease in body weight and weight gain at the end of the 3rd and 4th week post treatment beside improvement in feed consumption and feed conversion rate.
Effect on blood picture: Infected broiler treated with Phytobiotic and synbiotic together in tested dose showed in insignificant decrease in total erythrocytic count, haemoglobin content and packed cell volume beside insignificant increase in total leukocytic count, lymphocyte, heterophils, eosinophils, basophils and monocyte thought out the experimental period post treatment
Effect of on phagocytosis % and phagocytic index: Infected broiler treated with Phytobiotic and synbiotic together in tested dose showed in insignificant decrease in phagocytic activity and phagocytic index thought out the experimental period post treatment
Effect on IgM: Infected broiler treated with Phytobiotic and synbiotic together in tested dose showed in insignificant decrease in IgM thought out the experimental period post treatment when compared with non-infected non treated control broiler chickens.
Effect on Hemagglutinine inhibition titers against Newcastle disease vaccine: Infected broiler treated with Phytobiotic and synbiotic together in tested dose showed in insignificant decrease in hemagglutination inhibition titers against Newcastle disease vaccine thought out the experimental period post treatment
Effect on Protein picture: Infected broiler treated with Phytobiotic and synbiotic together in tested dose showed in insignificant decrease in serum total protein, serum albumin and albumin/ globulin Ratio coupled with insignificant increase in alpha, beta, gamma and total globulin thought out the experimental period post treatment
Effect on histopathology: Broiler chickens received phytobiotic and/or synbiotic in tested dose either alone or in combination from 1st day of age and at 14th day of age experimentally infected broilers with Clostridium perfringens showed mild pathological lesion.