الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 126 |  |  |
| | | from | 126 | | |
Abstract
Cisplatin is a highly effective antineoplastic DNA alkylating agent used against a wide variety of cancers. Its clinical use is associated with severe side-effects; including hepatotoxicity, ototoxicity, neurotoxicity and nephrotoxicity Cisplatin-induced nephrotoxicity through apoptosis and necrosis, vascular factors, oxidative stress and inflammation of the tubules. Natural antioxidant play vital role in defense system against oxidative stress induced by free radicals and reactive oxidative species. Parsely has anti-oxidant, anti-inflammatory and anti-apoptotic activity that induce nephroprotective effect. The present study was conducted to throw the light on the protective effect of parsley against cisplatin induced nephrotoxicity.
Experimental protocol
After one week of acclimatization, 50 adult male albino rats were randomly allocated into 5 equal groups each of 10 animals.
Group1 (Control): was orallry treated with sterile saline solution.
group 2 (Parsely): was given (0.42 ml parsley oil/ kg b.wt.) for 10 successive days orally.
group 3 (Cisplatin): was injected intraperitonealy with a single dose of (5mg /kg b.wt ) cisplatin on the 5th day . group 4 (Protective): was given 0.42 ml parsley oil / kg b.wt. orally for 10 days and rats were injected intraperitonealy with 5 mg cisplatin / kg .b.wt. on the 5th day.