الفهرس 
Cytotoxicity of current bioceramic sealersOnly 14 pages are availabe for public view
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Abstract
The aim of this study was to compare between 2 bioceramic sealers
(MTA-Fillapex and Endosequence) regarding their cytotoxicity,
biocompatibility and physical properties.
Materials and Methods:
Thirty discs (15 each sealer) were subdivided into 2 subgroups for
evaluation of cytotoxicity at 24 and 72 hours. Fifteen white female
Wistar-Furth rats were subdivided into three groups (5 rats each)
according to time of observation for biocompatibility evaluation. Eighty
discs (40 each sealer) were subdivided into three subgroups for evaluation
of radiopacity, initial setting time, and solubility. Twenty teeth were
decoronated, instrumented, dried and obturated using lateral compaction
technique for evaluation of adaptability using SEM. Two flat glass plates
16.2 mm diameters X 6.5-mm thick were used for film thickness
measurement (5 measurements for each sealer). Data was subjected to
statistical analysis.
Results:
MTA-Fillapex showed significantly higher cytotoxicity than
Endosequence sealer.
MTA-Fillapex showed significantly higher inflammatory cell count
and higher fibrous capsule thickness than Endosequence sealer .
Endosequence sealer showed longer initial setting time than MTA Fillapex
with a statistically significant difference between them.
Endosequence showed significantly higher weight loss than MTA Fillapex.
MTA-Fillapex showed higher radio-opacity value than
Endosequence with statistically significant difference between them.
Endosequence showed significantly higher film thickness than
MTA-Fillapex .Endosequence showed less percentage of gaps and better
adaptability than MTA-Fillapex with no statistically significant difference
between them.