الفهرس 
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Abstract
The purpose of our study was to compare the efficacy and safety of Trabeculectomy augmented by beta radiation and Mitomycin C with Trabeculectomy augmented by Mitomycin C only.
We conducted a prospective interventional open-label, non-randomized clinical study on Egyptian patients between October 2016 and January 2018, the study subjects included patients older than 18 years of age with primary or open angle glaucoma, Pigment dispersion glaucoma (PDG)) and chronic angle-closure glaucoma (CACG).
Patients with CACG or OAG with previous ocular surgery (including glaucoma surgery) or previous ocular trauma were excluded.
All participants underwent pre-operative complete ophthalmic examination, fundus examination and IOP measurement by Goldmann Applanation Tonometer.
Patients were assigned to 2 groups; trabeculectomy augmented by beta radiation and Mitomycin C or trabeculectomy augmented by Mitomycin C only. Patients were followed for 6 months. Primary outcome measure was final IOP measurements at 6-months follow up.
The study included 22 males and 28 females. Mean age of patients assigned to beta radiation with MMC and MMC only were 54.92±6.58, and 52.52±9.52 years respectively. POAG was diagnosed in 25 cases, CACG was diagnosed in 23 cases, PDG in 2 cases. Mean preoperative IOP in beta radiation with MMC group was 27.32±3.13, while in MMC only group was 28.00±2.50 with no significant difference among treatment groups. At 6-months follow up, mean IOP in beta radiation with MMC group was 15.52±1.45, while in MMC only group was 18.20±2.72. No inter-group significant difference was noticed at any scheduled postoperative follow up visit.
Preoperative IOP measurements were significantly, strongly and positively correlating with final IOP at 6 months (Pearson Correlation Coefficient; r = 0.339, p value = 0.034 in beta radiation with MMC group, while in MMC only group r =0.343, p value = 0.035. There was insignificant variable correlation between IOP measurements at 6 months and angle grading by gonioscopy, BCVA and CDR at Preoperative evaluation.
A complete success was achieved in 13 eyes (52%) in beta radiation with MMC group, while in MMC only group complete success was in 10 eyes (40%). Incomplete success was 12 eyes (48%) in beta radiation with MMC and 14 eyes (56%) in MMC only group. Surgical failure was reported in one case in control group.
On the light of the present data, we can conclude that single preoperative beta irradiation session to augment the effect of Mitomycin C in reducing postoperative IOP and bleb scarring may be a safe and effective alternative to MMC alone especially in Egyptian patients for improving the success rate of trabeculectomy surgery.