الفهرس 
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Abstract
Behcet’s disease is a systemic chronic relapsing inflammatory disorder that characterized by recurrent oral ulcers, genital ulcers, skin lesions and uveitis. The disease may involve major organ such as eye, CNS, or gastrointestinal tract. Objectives Our study aimed to estimate the level of vitamin D in Behçet’s disease patients and its relation to clinical manifestation and disease activity. Subjects and methods Behcet’s diseased patients (30 patients) with different disease activities diagnosed according to the International classification Criteria for Behcet’s disease and30 matched in age and sex , healthy individuals as a control group. The study was conducted on outpatient and inpatient of Physical Medicine, Rheumatology and Rehabilitation department and Ophthalmology center, Mansoura University, Egypt. All Behcet’s disease patients were subjected to:- Medical history. Clinical examination Disease activity assessment: assesment according to Behcet’s Disease Current Activity Form (BDCAF) score (2006). Laboratory investigations for Behcet’s disease includes serum calcium, phosphorus, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and alkaline phosphatase. Serum 25-hydroxyvitamin D (vitamin D) levels will be measured using (ELISA) Enzyme-Linked- Immunosorbent Assay. Control group was investigated for serum 25-hydroxyvitamin D using ELISA technique. Results Serum25 (OH)D level in BD patients was less than that in the control group. The frequency of vitamin D deficiency was (40%)in BD patients whereas in controls ,it was(20%),and the frequency of normal vitamin D level in BD was (6.7%) whereas in controls, it was (33.3%); the difference between the patients and controls was statistically significant(P=0.019). A significant correlation was detected between the25(OH)D level and the disease activity of BD patients (P>0.005). There was a non significant correlation between vitamin D levels and age of BD patients (P=0.17),disease duration ,clinical ,lab parameters of BD patients . There was no difference between serum vitamin D levels in patients who were on steroids, azathioprine or colchicine and those who did not receive these medications. Conclusion Serum vitamin D mean level is lower in Behect,s disease patients compared to healthy controls Vitamin D insufficiency and deficiency occurs at higher rate in Behçet’s disease patients.Vitamin D levels are significantly correlated with disease activity score. No significant association are detected between vitamin D levels and the age, disease duration, clinical and laboratory parameters of BD.