الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
 |  | from | 102 |  |  |
| | | from | 102 | | |
Abstract
Contrast-induced nephropathy (CIN) is an acute kidney injury (AKI) defined as serum creatinine (SCr) increase 48 to 72 hours after contrast administration. Because most subjects undergoing invasive cardiac procedures are discharged within 24 hours, SCr is unsuitable for CIN detection.
Neutrophil gelatinase - associated lipocalin (NGAL) also named Human neutrophil lipocalin (HNL), is a glycoprotein which exists as 25-kDa monomer belonging to the lipocalin superfamily.
Neutrophil gelatinase - associated lipocalin was originally identified in and purified from human neutrophils, it is also generally expressed at very low concentrations in a wide range of human tissues including kidney, trachea, lungs, stomach and colon.
Neutrophil gelatinase-associated lipocalin (NGAL) have been reported to be superior to SCr for the early diagnosis of CIN in patients who underwent coronary catheterizatio .
We therefore evaluated the role of serum NGAL as a new biomarker for early detection of CIN among high risk patients who underwent coronary angiography with/without intervention and to determine the frequency of CIN and the risk factors predisposing to CIN in these patients.
This was a prospective observational study carried out from January 2014 to July 2015. in the department of Cardiology, El-Minia University hospital.the study included Forty-two high risk patients, male/female 30/12, mean age 54.92±10.14(36-73) years, with mean baseline SCr 1.01±0.25 mg/dL (0.6 – 1.8 ) were enrolled. A contrast volume with mean 161.9±76.35 mL (range 100–300 mL) was administered. CIN was found in twelve subjects ( 28.6 %), but detection by SCr was only possible 48 h post-procedure.