الفهرس 
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Abstract
Sepsis is a life-threatening condition that arises when the body’s response to infection causes injury to its own tissues and organs.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.
The aim of our study was to evaluate serum Proprotein convertase subtilisin/kexin type 9 (PCSK9) level in children with sepsis and severe sepsis.
The study was carried out on 60 children, who were already diagnosed as having sepsis. They were classified into 2 groups. Sepsis group 1 which include 30 children and severe sepsis group 2 which include 30 children. Also, there is control group 3 which included 20 apparent healthy children.
Blood samples were withdrawn from all included children for complete blood picture (CBC), renal function tests, liver function test, lipid profile, blood culture, ABG and serum Proprotein convertase subtilisin/kexin type 9 (PCSK9).
In this study, we found that severe sepsis group suffered from acidosis and organ dysfunction more than sepsis group.PCSK9 and LDL-C levels were higher in the two sepsis groups than control group. Moreover, they were higher in the severe sepsis group than the sepsis group. PCSK9 in our study had predicted significantly hematological dysfunction. Furthermore, PCSK9 had a sensitivity of 100% in detecting renal and hepatic dysfunction.
In conclusion, PCSK9 level increases in sepsis and this increase can lead to organ failure development.The PCSK9 level was higher in the severe sepsis group than the sepsis group and this can explain the deterioration in the organ function occurring in the severe sepsis group. The LDL-C increased in the sepsis group than the control group and increased even more in the severe sepsis group. This corroborates the positive relationship between PCSK9 and LDL-C levels.