الفهرس 
EPIDEMIOLOGYOnly 14 pages are availabe for public view
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Abstract
Background: Head and neck cancer represents more than 550,000 cases annually. It accounts for 380,000 deaths every year. Despite aggressive treatment, only 35% to 55% of patients who present with locally advanced HNC cancer remain alive and free of disease 3 years after standard curative treatment. Thirty percent to 40% of patients develop locoregional recurrences, and distant metastases occur in 20% to 30%. Most recurrences appear quickly within 2 years of initial treatment and an additional 10% of patients will have evidence of distant metastases at the time of first presentation.
Purpose: To retrospectively determine the prognostic effect of T stage in locally advanced head and neck cancer.
Methods: This study retrospectively analyzed 40 patients diagnosed with locally advanced head and neck cancer. Patients were diagnosed by a tissue biopsy and they were staged by endoscope and CT neck or MRI neck with contrast. They received their treatment and were followed up every 3 months by CTs.
Results: We found a statistically significant correlation between T stage and both PFS and OS (95%, CI 1.00 – 3.10, p=0.04 and 95% CI 1.01 – 2.65, p=0.05 respectively).
Conclusion: This study confirmed that the T stage of the tumor is an important prognostic factor in locally advanced head and neck cancer.