Search In this Thesis
   Search In this Thesis  
العنوان
Complete versus limited axillary lymph node dissection in breast cancer /
المؤلف
Hany Saber GeorgyWessa
هيئة الاعداد
باحث / Hany Saber GeorgyWessa
مشرف / FateenAbdelmenemAnous
مشرف / SherifAbdelHalim Ahmed
مناقش / Tamer Mohamed Said
تاريخ النشر
2015.
عدد الصفحات
251p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
جراحة
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة عين شمس - كلية الطب - جراحة عامة
الفهرس
Only 14 pages are availabe for public view

from 251

from 251

Abstract

SUMMARY AND CONCLUSION
xillarylymphnodedissection (ALND)hasbeenan integral partofthe surgicaltreatment ofbreastcancersince thepopularizationoftheradicalmastectomy byWilliam Halsted in1894.Itwassuggested thatbreastcancerfirst spreadslocoregionallyvialymphaticstotheaxillarylymph nodes and thenmetastasizesmoredistantly. A tailored surgical approach with careful assessment of risks and benefits, together with patient preference, is guiding the evolving modern managementof the axilla (high accuracy and low morbidity) for women with early breast cancer. The role of ALND in survival of breast cancer patients has been a subject of debate. The status of the axillary nodes has long been considered to be the strongest prognostic factor in breast cancer and one of the most important determinants in the decision to use adjuvant systemic chemotherapy. However, as further understanding of breast tumor biology has been gained, the recommendation for adjuvant systemic therapy has shifted from nodal status as the major factor to other indicators of outcome such as tumor size, grade, receptor status, and breast cancer subtype.
A
Summary & Conclusion
185
Acceptance of the SLN procedureas a standard approachinsurgicalmanagementraisesthe questionofwhethercompleteALNDisnecessary inall patientswithpositiveSLN.Ithasbeenshown that SLN isthe only positive lymph node in38-67 %of patientswhenALNDfollowed.Thisfinding notonly provides strongsupport fortheSLNconcept,butalso suggests thatunnecessaryALNDcanbeavoidedinpatients with T1 tumor, becauseremovalofnegativelymphnodes doesnotprovideanysignificant benefit.
BCSincludes several techniques such as lumpectomy,quadrantectomy, and other oncoplastic techniques. BCS is preferred to be combined with axillary sampling, SLNB and limited axillary lymph node dissection with frozen which is our study (dissection of level 1 axillary lymph nodes with frozen).
The American College of Surgeons Oncology group Z0011 trial results provided convincing evidence that completion axillary lymph node dissection (CALND) was unnecessary in patients with 1 to 2 macrometastatic sentinel lymph nodes (SLNs). We hypothesized in our study that dissection of level 1 lymph nodes with frozen sufficient to detect status of the axilla to preclude the need for complete axillary dissection or axillary radiotherapy and in the same time avoid the complications of complete axillary dissection with its all subsequent morbidity such as lymphedema, pain, seroma, parasthesia and range of motion