الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 90 |  |  |
| | | from | 90 | | |
Abstract
The aim of this study was to evaluate the protective effect of Royal jelly against the destructive effect of cyclophosphamide on dental pulp in experimental animal model via biochemical, histopathological and immunohistochemical examination.
Twenty four male, adult, albino Wister rats, were randomly separated in to 4 groups of 6 rats each; control group which consisted of 6 rats which received 5 ml saline orally for 14 days, RJ group which consisted of 6 rats which received 300 mg/kg/day RJ orally by gastric tube for 14days; RJ capsules were be in the liquid form by containing 340 mg of royal jelly dissolved in distilled water according to the used dose , CP group which consisted of 6 rats in which rats received normal saline for 14days followed by a single dose of CP on the 15th day in a dose of 150 mg/kg intra-peritoneally and RJ / CP group which consisted of 6 rats in which rats received a daily oral dose 300 mg/kg/day of royal jelly for 14days by gastric tube followed by a single dose of 150 mg/kg intra-peritoneally of CP.
According to medication used; blood samples were collected from each rat for biochemical examination. The mandibles of rats were dissected and fixed in 10 % formaldehyde solution and transfer to the laboratory to be processed for histological and immunohistochemical examination. The data were statistically analyzed.
So we found that CP group showed marked biochemical, immunohistochemical, and histopathological changes when compared with the (C, RJ, CP/RJ) groups indicating destructive effect of CP administration. Concomitant administration of RJ with CP revealed a noticeable amelioration of all biochemical and histological changes indicating the protective effect of RJ.